BIOTOMATA

by Talos0248 · Released · checked Oct 20, 2026

Loading the game connects you to itch.io. The developer keeps the rights.

The short version

What is BIOTOMATA?

BIOTOMATA is a semi-active sci-fi incremental game with strategy and story elements. Players spend Biomatter on upgrades, use combat moves, manage a moveset, and work toward endings while optional settings adjust balancing and repetition.

BIOTOMATA is a semi-active sci-fi incremental game that mixes strategy and story. Play revolves around spending Biomatter on upgrades, using combat moves when they are ready, and handling enemies; a Decimate mechanic can one-shot enemies with 3x less combined stats than the player. Settings include Auto-Decimate, Challenge Mode for original strategy-oriented balancing, and options to remember auto-use moves and show combat and reset formulas. Three moveset loadout slots are available. Progression includes endings, an Endings Gallery, and Embers earned with unlocked endings. A Chrysalis screen shows icons for upgrades unlocked since last view.

Getting started

How to play BIOTOMATA

If the game loads stretched, click fullscreen and then unfullscreen to restore the correct aspect ratio.
Spend Biomatter with the upgrade button; long-hold it to keep spending without repeated clicks.
Use combat moves when ready, and long-hold a move icon to auto-use it.
Use Decimate on eligible enemies, or enable Auto-Decimate in settings to reduce decimation to 0 clicks.
Use the three moveset loadout slots to keep move setups.
Toggle Challenge Mode in settings to return to the original, more strategy-oriented balancing.

Controls

BIOTOMATA controls

InputAction

ClickRestore the aspect ratio by entering and leaving fullscreen if the game loads stretched

Long-holdContinuously spend Biomatter with the upgrade button

Double-clickMutate, with a minor confirmation prompt

Long-holdAuto-use a combat move when it is ready

ClickUse Decimate on eligible enemies

Settings toggleEnable Auto-Decimate, Challenge Mode, or remember auto-use moves

Controls are taken from the developer's itch.io page.

Play better

Tips for BIOTOMATA

If the game loads stretched, click fullscreen then unfullscreen to restore the correct aspect ratio.
Long-hold the upgrade button to continuously spend Biomatter instead of repeated clicks.
Long-hold a move icon to auto-use combat moves when ready; settings can remember auto-use moves.
Auto-Decimate in settings reduces decimation to 0 clicks.
Challenge Mode reverts to the original, more strategy-oriented balancing.

Questions

BIOTOMATA FAQ

What is BIOTOMATA?

It is a semi-active sci-fi incremental game with strategy and story elements.

How do I fix a stretched game view?

Click fullscreen, then unfullscreen to restore the correct aspect ratio.

Is there a way to spend Biomatter faster?

Long-hold the upgrade button to continuously spend Biomatter instead of clicking repeatedly.

What does Decimate do?

It one-shots enemies with 3x less combined stats than the player with a single button click.

Can I return to the original balancing?

Yes, the Challenge Mode toggle in settings reverts to the original, more strategy-oriented balancing.

Are endings part of the game?

Yes, unlocked endings grant more Embers to spend, and an Endings Gallery is included.

From the developer

About this game

Read the full developer description

Deep beneath, a chrysalis stirs...

BIOTOMATA is a semi-active, sci-fi themed incremental with elements of strategy and story.

Note to Itch.io players:

If the game loads to a weird aspect ratio (i.e. super stretched), click on fullscreen then unfullscreen to restore the correct aspect ratio! (This likely has to do will how the game detects mobile layout on load, and how itch.io resizing the game window doesn't properly trigger the window resize listener in-game. Appreciate your patience!)

For new players:

I hope you'll enjoy the game! :D

For returning players:

Welcome back! Many new QoL updates have been added since the first launch, including:

Endgame balancing: You now get more Embers to spend with each unlocked ending! A "Challenge Mode" toggle is added to settings to revert back to the original, more strategy-oriented balancing. This change is made to hopefully accommodate both the "I love numbers go up and becoming OP!" crowd and the "I love strategy in incrementals!" crowd <3
Additional 25K starting mutagen upon reaching level 35 as an extra boost to ending hunters.
New "Decimate" mechanic. One-shot enemies with 3x less combined stats than you with a single button click.
"Auto-Decimate" option in settings to effectively reduce decimation to 0 clicks.
Auto-use combat moves when ready by long-holding the move icon. (Should reduce early-game repetitiveness)
Option to remember auto-use moves in settings.
Added settings option to show combat and reset formulas.
Three moveset loadout slots! (Old moveset will need to be reassigned to account for new save structure, apologies in advance!)
Instead of repeat clicks, you can now long hold the upgrade button to continuously spend Biomatter.
"Double click to mutate" now has a minor confirmation prompt.
Chrysalis now has icons which indicate which upgrades have been unlocked since last view.
On mobile, scroll position of the cascade screen is now saved.
Status effect tooltips on Moveset description screen.
Info screen with updated credits.
Endings Gallery.

I also hope you'll enjoy the game! :D

Description from BIOTOMATA on itch.io, by Talos0248.

Screens

Screenshots

Not listed by the developer: release date, mobile platform support, keyboard controls, system requirements. We left these out rather than guess.